By Charlie Bresler, The Life You Can Save The Life You Can Save (TLYCS) is an organization founded by the philosopher Peter Singer and based on the basic tenet of Effective Altruism: leading an ethical life involves using a portion of personal wealth and resources to efficiently alleviate the effects of extreme poverty. PSI is one of twelveRead More ›
PSI experts presenting data and leading discussions at 63rd annual meeting
By Mandy McAnally, PSI Bill Gates, co-chair of the Bill & Melinda Gates Foundation, kicked off the 63rd Annual Meeting of the Society of Hygiene and Tropical Medicine in New Orleans, L.A. to a grand ovation. “I really do believe malaria can be eradicated in my lifetime,” he said to a packed ballroom, noting. “IRead More ›
VIDEO: CNN spoke with Mandy Moore about her recent trip to Tanzania with PSI
The video accompanied an op-ed piece by Moore, explaining what she learned about how PSI uses the social franchise model to support all aspects of running a small clinic: Dr. John said what he most needed was better business management skills. He was most appreciative about that component of PSI’s franchise model — the ongoingRead More ›
Lining up to eliminate a major threat to humankind – Part 3
PSI Senior Vice President for Malaria Control and Child Survival Dr. Desmond Chavasse blogs about his recent trip to Cambodia and PSI’s work to eliminate drug-resistant malaria in Southeast Asia. Below is part 3 of 3. (read part 1 or part 2) PSI, and others, have learned a great deal about malaria in Southeast Asia with the helpRead More ›
Lining up to eliminate a major threat to humankind – Part 2
PSI Senior Vice President for Malaria Control and Child Survival Dr. Desmond Chavasse blogs about his recent trip to Cambodia and PSI’s work to eliminate drug-resistant malaria in Southeast Asia. Below is part 2 of 3. (read part 1) After Bill and Melinda Gates visited PSI in Cambodia, I spent several days there with myRead More ›
Lining up to eliminate a major threat to humankind - Part 1
PSI Senior Vice President for Malaria Control and Child Survival Dr. Desmond Chavasse blogs about his recent trip to Cambodia and PSI’s work to eliminate drug-resistant malaria in Southeast Asia. Below is part 1 of 3. Why Malaria, Why Southeast Asia, Why now? I first met Bill Gates for dinner in Nairobi in 2008. HisRead More ›
Today, for World Health Day this year, the World Health Organization has chosen to highlight the serious and increasing threat of vector-borne diseases. Every year, more than one billion people are infected and more than one million die from these diseases, which include malaria, dengue, leishmaniasis, lyme disease, schistosomiasis, and yellow fever, carried by mosquitoes, flies, ticks, water snails and other vectors.Read More ›
The Global Fund to Fight AIDS, TB and Malaria is seeking to raise $15 billion in its new replenishment, this week. There will be a lot of discussions and reports about the vital organzation. Here are two new videos form the Center for Strategic International Studies out of Washington DC.
The first video looks at the Global Fund and the importance of the US as a major financial supporter to its work. This is a good video for those of you that are not familiar with the Fund. It answers the questions: what is the Fund and its mission? What impact has it had? What will it take to sustain its success?
Next up, Gayle Smith, Special Assistant to the President and a Senior Director at the National Security Council, explains why the Global Fund matters today and discusses the United States’ leadership role in supporting the Fund.Read More ›
Clear metrics can be hard to come by, but there are no shortage of indicators pointing to the critical moment in which we find ourselves with respect to AIDS, tuberculosis and malaria. Worldwide efforts have reduced HIV incidence by 33 percent, tuberculosis deaths by more than 40 percent, and malaria deaths in Africa by 33Read More ›
In the poorest countries of the world, millions of people still suffer and die from easily preventable diseases like malaria, tuberculosis and polio. The world has responded to this scandal by pouring billions of dollars of aid into health through organizations like the Global Fund to Fight AIDS, Tuberculosis and Malaria and the GAVI Alliance.Read More ›
Some exciting developments in the quest to create a safe and effective malaria vaccine were announced at a conference in Durban, South Africa late yesterday afternoon.
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The efficacy and public health impact of RTS,S were evaluated in the context of existing malaria control measures, such as insecticide treated bed nets, which were used by 78% of children and 86% of infants in the trial. In these latest results over 18 months of follow-up, children aged 5-17 months at first vaccination with RTS,S experienced 46% fewer cases of clinical malaria, compared to children immunised with a control vaccine. An average of 941 cases of clinical malaria were prevented over 18 months of follow-up for every 1,000 children vaccinated in this age group, noting that a child can contract more than one case of malaria. Severe malaria cases were reduced by 36%; 21 cases of severe malaria were prevented over 18 months of follow-up for every 1,000 children vaccinated. Malaria hospitalisations were reduced by 42%.
Infants aged 6-12 weeks at first vaccination with RTS,S had 27% fewer cases of clinical malaria. Over 18 months of follow-up, 444 cases of clinical malaria were prevented for every 1,000 infants vaccinated. The reduction of severe malaria cases and malaria hospitalisations by 15% and 17%, respectively, were not statistically significant.
“It appears that the RTS,S candidate vaccine has the potential to have a significant public health impact,” says Tinto. “Preventing substantial numbers of malaria cases in a community would mean fewer hospital beds filled with sick children. Families would lose less time and money caring for these children and have more time for work or other activities. And of course the children themselves would reap the benefits of better health.”
Overall, vaccine efficacy declined over time: Previous results from one year follow-up of the Phase 3 trial showed that efficacy of RTS,S was 56% against clinical malaria and 47% against severe malaria for the 5-17 month-old age group and 31% against clinical malaria and 37% against severe malaria in the 6-12 week-old age group.
The Global Fund to Fight AIDS, Tuberculosis and Malaria released their mid-year results for 2013. The numbers are very exciting.
More than 5.3 million people living with HIV receive ARVs thanks to the Global Fund. The findings also observe a 21% increase in the number of women treated to prevent mother-to-child transmission of HIV.
“These results show that we can have a transformative effect on these diseases, by working together,” said Mark Dybul, Executive Director of the Global Fund. “More people affected by HIV today can go to work, send their children to school and lead healthy lives thanks to the hard work of all our partners.”
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Big strides have also been made in the fight against malaria, with 30 million insecticide-treated nets distributed in the first half of 2013 under programs supported by the Global Fund, taking the total number of nets distributed to 340 million. The number of cases of malaria treated rose to 330 million, a 13 percent increase.
Global Fund-supported TB programs also continued to expand. Global Fund financing has cumulatively supported detection and treatment of 11 million smear-positive cases of TB, up from 9.7 million at the end of 2012. The number of people treated for multidrug-resistant TB grew to 88,000 from 69,000 through Global-Fund supported programs. The World Health Organization reported that 56,000 cases were enrolled in treatment of multidrug-resistant TB globally in 2011, of which Global Fund-supported programs accounted for about 22 percent. India drove the leap forward, accounting for about 60 percent of the increase at the end of 2012.