European scientists are on the cusp of another breakthrough in the fight against malaria.
Researchers from Britain and France said they had identified genes in the Plasmodium falciparum parasite which produce enzymes called kinases.
Thirty-six kinases are needed for the parasite to develop in human blood cells, a key part of its complex life cycle, they reported in the journal Nature Communications.
“We are now looking for drugs that… stop the protein kinases from working. If we find these drugs then we will have a new way of killing the malaria parasite,” said Christian Doerig of France’s Institut National de la Sante et de la Recherche Medicale (Inserm).
Andrew Tobin of Britain’s University of Leicester said the search for a new weapon was vital, given the parasite’s dismaying ability to build resistance against treatment.
“It seems perfectly realistic to us that we can now develop novel anti-malaria drugs based on the findings that we have made — it certainly is a big moment in our fight against this terrible disease that mainly affects the world?s poorest people,” he said in a press release issued by the university.
The research is a further step, at research level, in identifying chinks in malaria’s armour.
Earlier this month, a team at Britain’s Wellcome Trust Sanger Institute said they had discovered a single microscopic channel through which P. falciparum must pass in order to infect red blood cells.
Intrusion depends on the interaction between a specific molecule on the parasite, called a ligand, and a specific receptor on the surface of the blood cell.
Blocking this lock-and-key interaction prevents the parasite from breaching the cell wall.
In October, early results from clinical trials among African children showed that the world’s first malaria vaccine cut infection rates by roughly half.
The so-called RTS,S vaccine, made by the British pharmaceutical giant GlaxoSmithKline, is the first of its kind to prime the immune system against a parasite, rather than a bacterium or a virus.
Madhura Bhat is Associate Manager, Corporate Marketing, for PSI in Washington.
I recently returned from an inspirational trip to Rwanda. I say inspirational, because it impressed upon me the work that PSI does and the impact our programs have in the communities we serve. It also reminded me of two peer educators I met from our Vietnam program, Huong and Cuong who shared with me their stories of empowerment and hope. They worked diligently to motivate their communities to fight HIV. In doing this work, they found fulfillment, confidence and hope for themselves and their families. Their video stories are below.
The Center for Health Market Innovations has released its annual report that maps and highlights innovations from the past year. One of the featured innovations is social franchising, a space where PSI is very active. The example used by CHMI is PSI’s very own Sun Quality Health in Myanmar:
CHMI documents over 60 social franchises operating in over 30 countries around the world. Franchising has gained popularity in recent years as an effective mechanism to organize independent private providers to offer a range of quality health services. Family planning and reproductive health services are key areas of focus for most documented franchises, but many programs are beginning to expand beyond these two areas, leveraging their platforms to deliver TB, HIV/AIDS, and malaria interventions. Franchises are also emerging as a potential service delivery mechanism for the screening and treatment of chronic diseases. In Myanmar,Sun Quality Health is beginning to offer low-cost cervical cancer screenings and cryotherapy (the use of cold temperatures to destroy abnormal tissue) through its network of franchised clinics. Similar initiatives are underway in Kenya and Uganda.
16 aid organizations, including UNICEF, UNHCR and Concern, were evicted from Somalia by the rebel group Al Shabaab.Reuters reports:
The move comes as aid groups battle to stem a famine that has left a quarter of a million Somalis in danger of starvation and Kenyan, Somali and Ethiopian forces fight the al-Qaeda-inspired rebels in the south and center of the country.
Al-Shabaab, which controls large areas of the anarchic Horn of Africa country, said it had “decided to permanently revoke the permissions of the following organizations to operate inside Somalia.”
It listed the U.N. High Commissioner for Refugees (UNHCR), the World Health Organization (WHO), the United Nations Children’s Fund (UNICEF) and the Norwegian and Danish Refugee Councils among others.
Some organizations were found to be “persistently galvanizing the local population against the full establishment of the Islamic Sharia system,” the group said in a statement.
Pieter Desloovere, WHO Somalia’s communications officer, confirmed WHO’s offices in the Somali towns of Baidoa and Wajid had been attacked on Monday.
UNICEF’s Jaya Murthy told Reuters the agency’s offices had been occupied by al-Shabaab in the southern-central town of Baidoa on Monday.
“All of our staff that were in the office at the same time were asked to leave. All of our staff are safe. Our Baidoa office is currently still being occupied. No other UNICEF office is currently being occupied and all staff in Somalia are safe,” Murthy told Reuters in Geneva.
It is that time of year when all of the lists of doers, thinkers and innovators begin to pop up. Foreign Policy makes an early entry into listicle season with its annual “Top 100 Global Thinkers.” The first 10 this year are activists involved in Arab Spring. The ensuing 90 are philanthropists, academics, writers, and advocates from around the world.
We have complied a listing of some of the people honored who have an impact on global health, foreign aid and international development.
There are some who made the list and are not here and many others who did not make the cut according to FP. Let us know who you think should have been included in the comments section.
In an interview with Charles Kenny of the Center for Global Development, Bill and Melinda Gates reveal what promising innovations spark their interest and share their hopes for the future of aid in development.
On working with governments on aid:
Within our areas of expertise, which include health and agriculture, some financial services, water, and sanitation, we are willing to really celebrate the great successes where rich-country aid budgets are funding things that are quite successful. We spend over $3 billion a year, of which $2 billion gets spent outside the United States, on these issues of helping the poorest countries. Getting the word out there — [so] that people know that when the U.S is spending on malaria bed nets it’s making a difference; or when Europe is funding new agricultural things, that that’s worked out; or The Global Fund or GAVI Alliance are doing great work — we spent quite a bit of time on that. Certainly at this G20 meeting [in November] we are encouraging rich countries and middle-income countries to spend their aid well and not to reduce their generosity lower than the minimum necessary.
Australian researchers have discovered that the malaria parasite can survive in a type of white blood cell in the spleen.
Traditionally, it was believed the parasite’s development was restricted to the liver and red blood cells.
Michelle Wykes, who conducted the study from the Queensland Institute of Medical Research (QIMR), said the findings open up a whole new approach to developing drugs and vaccines, the journal Proceedings of the National Academy of Sciences reports.
“Our research has discovered how white blood cells called dendritic cells malfunction and shield the malaria parasite from the body`s immune attack.
“Dendritic cells normally function like generals of an army, giving orders to the body`s immune cells to fight infection,” QIMR quoted Wykes as saying.
“The system usually works brilliantly. However, the problem with malaria is that the disease has found a way to block dendritic cells from doing their work, meaning the disease over-rides our immune responses. (So) people get sick,” said Wykes.
ED note. This post is from Leif Redmond, Communications Manager for PSI in Washington.
Social franchising improves access, quality, equity, and cost-effectiveness of health service delivery. This we know. By replicating a successful business model, social franchising enables the coordination of health services by private providers to meet the needs of the poor. PSI has 15 years of experience in social franchising and delivers service to 13.5 million clients annually in 22 countries through to 16,000 social franchisees.
The following post is by PSI CEO and President Karl Hofmann.It is cross posted on our special SF4Health Conference blog.
We are in an era of real concern about costs, of flat or declining budgets for development and value-for-money of development spending. This sort pressure focuses global health NGOs on how to better meet the needs of our target audiences and deliver better value to them.
Social franchising has a proud history and impressive achievements to its name. Today PSI is a large part of the social franchising movement across the world. PSI’s 16,000 social franchisees currently deliver essential health services to an estimated 13.5 million clients in 22 countries worldwide.
It’s time to consider where we are headed and how we can improve. I’d like to propose six key areas for PSI and social franchising going forward.